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What it does allow for for, under ailments of very low oxygen concentration, could be the polymerization on the HbS itself. The deoxy type of haemoglobin exposes a hydrophobic patch on the protein in between the E and F helices (Phe 85, Leu 88). The hydrophobic side chain of the valine residue at posture six of the beta chain in haemoglobin is read

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